Pub. Date : 2005 Jul
PMID : 15995183
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Escherichia coli HypA is a zinc metalloprotein with a weak affinity for nickel. | Nickel | hypA | Escherichia coli |
| 2 | HypA or a homologous protein is required for nickel insertion into the hydrogenase precursor proteins. | Nickel | hypA | Escherichia coli |
| 3 | Fluorescence titration experiments demonstrate that HypA binds nickel with micromolar affinity and that the presence of zinc does not dramatically affect the nickel-binding activity. | Nickel | hypA | Escherichia coli |
| 4 | Finally, complex formation between HypA and HypB, another accessory protein required for nickel insertion, was observed. | Nickel | hypA | Escherichia coli |
| 5 | These experiments suggest that HypA is an architectural component of the hydrogenase metallocenter assembly pathway and that it may also have a direct role in the delivery of nickel to the hydrogenase large subunit. | Nickel | hypA | Escherichia coli |