Title : Induction and degradation of the uncoupling protein thermogenin in brown adipocytes in vitro and in vivo. Evidence for a rapidly degradable pool.

Pub. Date : 1992 Jun 1

PMID : 1599423






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In cell cultures stimulated for only 24 h, the induced thermogenin was subsequently specifically and rapidly degraded, with a half-life of 20 h. As the half-life was prolonged by cycloheximide treatment, the degradation was apparently due to the induction of specific proteins after cessation of adrenergic stimulation. Cycloheximide uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus
2 In cell cultures continuously stimulated with noradrenaline for 5 days, the induced thermogenin was degraded much more slowly after noradrenaline removal, with a half-life of 70 h. This half-life was unchanged by cycloheximide treatment, and the degradation after cycloheximide was in parallel with the degradation of protein in general, and was therefore non-specific. Cycloheximide uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus
3 In cell cultures continuously stimulated with noradrenaline for 5 days, the induced thermogenin was degraded much more slowly after noradrenaline removal, with a half-life of 70 h. This half-life was unchanged by cycloheximide treatment, and the degradation after cycloheximide was in parallel with the degradation of protein in general, and was therefore non-specific. Cycloheximide uncoupling protein 1 (mitochondrial, proton carrier) Mus musculus