Title : Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway.

Pub. Date : 2005 Aug 26

PMID : 15983046






1 Functional Relationships(s)
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Protein Name
Organism
1 Ubiquitination of Keap1 is markedly increased in cells exposed to quinone-induced oxidative stress, occurs in parallel with inhibition of Keap1-dependent ubiquitination of Nrf2, and results in decreased steady-state levels of Keap1, particularly in cells that are unable to synthesize glutathione. quinone NFE2 like bZIP transcription factor 2 Homo sapiens