Title : Ceramide regulation of the tumor suppressor phosphatase PTEN in rafts isolated from neurotumor cell lines.

Pub. Date : 2005 Aug 15

PMID : 15968641






1 Functional Relationships(s)
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1 Here we present evidence that ceramide recruits the tumor suppressor PTEN (phosphatase and tensin homolog deleted from chromosome 10) into membrane microdomains (rafts), where it could act to reduce the levels of polyphosphoinositides necessary for the activation of Akt. Phosphatidylinositol Phosphates phosphatase and tensin homolog Homo sapiens