Title : Miscoding events during DNA synthesis past the nitration-damaged base 8-nitroguanine.

Pub. Date : 2005 Jun 28

PMID : 15966748






1 Functional Relationships(s)
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1 Primer extension reactions catalyzed by pol alpha or beta were strongly retarded at the 8-NO(2)-dG lesion; a fraction of primers was extended past the lesion by incorporating preferentially dCMP, the correct base, opposite the lesion, accompanied by lesser amounts of dAMP and dGMP incorporation. Deoxycytidine Monophosphate DNA polymerase alpha 1, catalytic subunit Homo sapiens