Title : The antitumor and antiangiogenic activity of vascular endothelial growth factor receptor inhibition is potentiated by ErbB1 blockade.

Pub. Date : 2005 Jun 15

PMID : 15958638






3 Functional Relationships(s)
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1 RESULTS: Both ErbB inhibitors significantly enhanced the antitumor activity of PTK787/ZK222584. vatalanib epidermal growth factor receptor Homo sapiens
2 RESULTS: Both ErbB inhibitors significantly enhanced the antitumor activity of PTK787/ZK222584. vatalanib epidermal growth factor receptor Homo sapiens
3 Under basal condition, both ZD1839 and PTK787/ZK222584 blocked sprouting, likely via inhibition of an autocrine ErbB1 loop and VEGFR signaling, respectively, in endothelial cells. vatalanib epidermal growth factor receptor Homo sapiens