Title : Inhibition or knock out of inducible nitric oxide synthase result in resistance to bleomycin-induced lung injury.

Pub. Date : 2005 Jun 14

PMID : 15955252






1 Functional Relationships(s)
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1 When compared to bleomycin-treated iNOSWT mice, iNOSKO mice, which had received bleomycin, exhibited a reduced degree of the (i) lost of body weight, (ii) mortality rate, (iii) infiltration of the lung with polymorphonuclear neutrophils (MPO activity), (iv) edema formation, (v) histological evidence of lung injury, (vi) lung collagen deposition and (vii) lung Transforming Growth Factor beta1 (TGF-beta1) expression. Bleomycin myeloperoxidase Mus musculus