Title : Lipoxin A4 inhibits TNF-alpha-induced production of interleukins and proliferation of rat mesangial cells.

Pub. Date : 2005 Jul

PMID : 15954894






1 Functional Relationships(s)
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1 BACKGROUND: Studies have shown that lipoxin A(4) (LXA(4)) and its analogues inhibited proliferation of glomerular mesangial cells induced by leukotriene D(4) (LTD(4)) or platelet-derived growth factor (PDGF), reduced the production of proinflammatory cytokines such as interleukin (IL)-1beta and IL-6 in renal tissue of ischemic injury. lipoxin A4 interleukin 6 Rattus norvegicus