Pub. Date : 2005 Mar
PMID : 15952644
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | OBJECTIVE: This study was to investigate the effect of crocidolite fibers on IL-8 protein and mRNA levels in A549 cells cultured supernatant and the role of tyrosine kinase inhibitor PD98059 on IL-8 expression. | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 2 | RESULTS: After incubating cells with 100 microg/ml of crocidolite, IL-8 protein releasing in supernatant was significantly increased and IL-8 mRNA was also higher than that of control, the differences were statistically significant (P < 0.05), however both IL-8 protein and mRNA was abrogated by pretreating cells with tyrosine kinase inhibitor PD98059. | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 3 | CONCLUSION: IL-8 was shown as overexpression and could be decreased by PD98059. | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one | C-X-C motif chemokine ligand 8 | Homo sapiens |