Pub. Date : 2005 Sep
PMID : 15947421
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Bleomycin-induced lung injury triggers a profound and durable increase in tissue inhibitor of metalloproteinase (TIMP)-1 expression, suggesting a potential role for this antiproteinase in the regulation of lung inflammation and fibrosis. | Bleomycin | tissue inhibitor of metalloproteinase 1 | Mus musculus |
| 2 | Using TIMP-1 null mutation mice, we demonstrate that TIMP-1 deficiency amplifies acute lung injury as determined by exaggerated pulmonary neutrophilia, hemorrhage, and vascular permeability compared with wild-type littermates after bleomycin exposure. | Bleomycin | tissue inhibitor of metalloproteinase 1 | Mus musculus |