Title : Gene dosage determines the negative effects of polymorphic alleles of the P2X7 receptor on adenosine triphosphate-mediated killing of mycobacteria by human macrophages.

Pub. Date : 2005 Jul 1

PMID : 15942904






1 Functional Relationships(s)
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1 CONCLUSIONS: Various polymorphisms in P2X7 abrogate IFN- gamma /ATP-induced killing of mycobacteria by human macrophages and, thus, may contribute to variability in susceptibility to mycobacterial infections. Adenosine Triphosphate interferon gamma Homo sapiens