Title : Cyclo-oxygenase-1 and -2 differently contribute to prostaglandin E2 synthesis and lipid peroxidation after in vivo activation of N-methyl-D-aspartate receptors in rat hippocampus.

Pub. Date : 2005 Jun

PMID : 15935072






1 Functional Relationships(s)
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1 The formation of the two metabolites--produced through cyclo-oxygenase (COX) enzymatic activity and free radical-mediated peroxidation of arachidonic acid (AA), respectively,--was prevented by the specific NMDA antagonist MK-801, and was largely dependent on COX-2 activity. Arachidonic Acid cytochrome c oxidase II, mitochondrial Rattus norvegicus