Title : EWS-FLI1 fusion protein up-regulates critical genes in neural crest development and is responsible for the observed phenotype of Ewing's family of tumors.

Pub. Date : 2005 Jun 1

PMID : 15930281






1 Functional Relationships(s)
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1 To test whether EWS-FLI1 fusion gene expression is responsible for the primitive neuroectodermal phenotype of EFT, we established a tetracycline-inducible EWS-FLI1 expression system in a rhabdomyosarcoma cell line RD. Tetracycline Fli-1 proto-oncogene, ETS transcription factor Homo sapiens