Pub. Date : 2005
PMID : 15921025
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nifedipine inhibits tumor necrosis factor-alpha-induced upregulation of monocyte chemoattractant protein-1 mRNA levels by suppressing CD40 expression in endothelial cells. | Nifedipine | C-C motif chemokine ligand 2 | Homo sapiens |
| 2 | We have previously shown that nifedipine, one of the most popular DHPs, inhibits tumor necrosis factor-alpha (TNF-alpha)-induced reactive oxygen species generation and subsequent monocyte chemoattractant protein-1 (MCP-1) expression in human umbilical vein endothelial cells (HUVEC). | Nifedipine | C-C motif chemokine ligand 2 | Homo sapiens |
| 3 | We have previously shown that nifedipine, one of the most popular DHPs, inhibits tumor necrosis factor-alpha (TNF-alpha)-induced reactive oxygen species generation and subsequent monocyte chemoattractant protein-1 (MCP-1) expression in human umbilical vein endothelial cells (HUVEC). | Nifedipine | C-C motif chemokine ligand 2 | Homo sapiens |
| 4 | In this study, we investigated the involvement of CD40 in MCP-1 suppression by nifedipine in TNF-alpha-exposed HUVEC. | Nifedipine | C-C motif chemokine ligand 2 | Homo sapiens |
| 5 | These results demonstrate that nifedipine could inhibit the TNF-alpha-induced upregulation of MCP-1 mRNA levels via suppression of CD40 expression in HUVEC. | Nifedipine | C-C motif chemokine ligand 2 | Homo sapiens |