Pub. Date : 2005 Apr
PMID : 15920909
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Induction of the ABC-transporters Mdr1/P-gp (Abcb1), mrpl (Abcc1), and bcrp (Abcg2) during establishment of multidrug resistance following exposure to mitoxantrone. | Mitoxantrone | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | Induction of the ABC-transporters Mdr1/P-gp (Abcb1), mrpl (Abcc1), and bcrp (Abcg2) during establishment of multidrug resistance following exposure to mitoxantrone. | Mitoxantrone | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | Resistance to mitoxantrone is often associated with enhanced drug efflux mediated by members of the superfamily of adenosinetriphosphate-binding cassette (ABC) transporters, i.e. MDR1/P-gp (ABCB1), MRP1 (ABCC1), or BCRP (ABCG2). | Mitoxantrone | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | Resistance to mitoxantrone is often associated with enhanced drug efflux mediated by members of the superfamily of adenosinetriphosphate-binding cassette (ABC) transporters, i.e. MDR1/P-gp (ABCB1), MRP1 (ABCC1), or BCRP (ABCG2). | Mitoxantrone | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 5 | Here, we demonstrate that the expression of all three extrusion pumps is induced by increasing levels of mitoxantrone resistance, but in the end, merely the overexpression of a dominant single drug transporter, i.e. Mdr1/P-gp, is realized. | Mitoxantrone | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 6 | Short mitoxantrone exposure demonstrated that upregulation of two different transporters, Mdr1/P-gp and Bcrp, was induced. | Mitoxantrone | ATP binding cassette subfamily B member 1 | Homo sapiens |