Pub. Date : 2005 Jun
PMID : 15911030
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Mesuol, a natural occurring 4-phenylcoumarin, inhibits HIV-1 replication by targeting the NF-kappaB pathway. | 4-phenylcoumarin | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | In addition, mesuol inhibits TNFalpha-induced HIV-1-LTR transcriptional activity by targeting the nuclear factor-kappaB (NF-kappaB) pathway. | 4-phenylcoumarin | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | These results highlight the potential of the NF-kappaB transcription factor as a target for anti-HIV-1 compounds such as 4-phenyl coumarins, which could serve as lead compounds for the development of additional therapeutic approaches against AIDS. | 4-phenylcoumarin | nuclear factor kappa B subunit 1 | Homo sapiens |