Title : Oleoylethanolamide, an endogenous PPAR-alpha agonist, lowers body weight and hyperlipidemia in obese rats.

Pub. Date : 2005 Jun

PMID : 15910890






4 Functional Relationships(s)
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1 Oleoylethanolamide, an endogenous PPAR-alpha agonist, lowers body weight and hyperlipidemia in obese rats. oleoylethanolamide peroxisome proliferator activated receptor alpha Rattus norvegicus
2 Oleoylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha. oleoylethanolamide peroxisome proliferator activated receptor alpha Rattus norvegicus
3 In the present study, we report that subchronic OEA treatment (5mgkg(-1), intraperitoneally, i.p., once daily for two weeks) in Zucker rats initiates transcription of PPAR-alpha and other PPAR-alpha target genes, including fatty-acid translocase (FAT/CD36), liver fatty-acid binding protein (L-FABP), and uncoupling protein-2 (UCP-2). oleoylethanolamide peroxisome proliferator activated receptor alpha Rattus norvegicus
4 In the present study, we report that subchronic OEA treatment (5mgkg(-1), intraperitoneally, i.p., once daily for two weeks) in Zucker rats initiates transcription of PPAR-alpha and other PPAR-alpha target genes, including fatty-acid translocase (FAT/CD36), liver fatty-acid binding protein (L-FABP), and uncoupling protein-2 (UCP-2). oleoylethanolamide peroxisome proliferator activated receptor alpha Rattus norvegicus