Title : Regulation of the proapoptotic activity of huntingtin interacting protein 1 by Dyrk1 and caspase-3 in hippocampal neuroprogenitor cells.

Pub. Date : 2005 Jul 1

PMID : 15906374






4 Functional Relationships(s)
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Protein Name
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1 Furthermore, the addition of etoposide to proliferating H19-7 cells caused the diminished binding of Hip-1 to Dyrk1 and the levels of phosphorylated Hip-1 remarkably decreased. Etoposide huntingtin interacting protein 1 Rattus norvegicus
2 Furthermore, the addition of etoposide to proliferating H19-7 cells caused the diminished binding of Hip-1 to Dyrk1 and the levels of phosphorylated Hip-1 remarkably decreased. Etoposide huntingtin interacting protein 1 Rattus norvegicus
3 Simultaneously, the dissociated Hip-1 from Dyrk1 bound to caspase-3 in response to etoposide, which led to its activation and consequently cell death in H19-7 cells. Etoposide huntingtin interacting protein 1 Rattus norvegicus
4 The interaction between Dyrk1 and Hip-1 appeared to be differentially modulated by different kinds of stimuli, such as bFGF and etoposide in H19-7 cells. Etoposide huntingtin interacting protein 1 Rattus norvegicus