Title : 4-Hydroxyestradiol induces oxidative stress and apoptosis in human mammary epithelial cells: possible protection by NF-kappaB and ERK/MAPK.

Pub. Date : 2005 Oct 1

PMID : 15901486






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 4-Hydroxyestradiol (4-OHE2), an oxidized metabolite of E2 formed preferentially by cytochrome P450 1B1, reacts with DNA to form depurinating adducts thereby exerting genotoxicity and carcinogenicity. 4-hydroxyestradiol cytochrome P450 family 1 subfamily B member 1 Homo sapiens
2 4-Hydroxyestradiol (4-OHE2), an oxidized metabolite of E2 formed preferentially by cytochrome P450 1B1, reacts with DNA to form depurinating adducts thereby exerting genotoxicity and carcinogenicity. 4-hydroxyestradiol cytochrome P450 family 1 subfamily B member 1 Homo sapiens