Title : Interference free and simplyfied liquid chromatography-based determination of thiopurine S-methyltransferase activity in erythrocytes.

Pub. Date : 2005 Jul 5

PMID : 15897017






1 Functional Relationships(s)
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1 We therefore, established an optimized and fast isocratic HPLC linked TPMT assay based on the enzymatic methylation of mercaptopurine or thioguanine in RBC lysates with S-adenosyl-l-methionine as methyl donor. S-Adenosylmethionine thiopurine S-methyltransferase Homo sapiens