Title : Induction of phase-1 metabolizing enzymes by oltipraz, flavone and indole-3-carbinol enhance the formation and transport of benzo[a]pyrene sulfate conjugates in intestinal Caco-2 cells.

Pub. Date : 2005 Aug 14

PMID : 15890477






2 Functional Relationships(s)
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1 In summary, our study shows that the induction of both CYP1A1 and CYP1B1 resulted in an accelerated metabolism and an enhanced clearance of the potent procarcinogen BP, indicating that flavone, indole-3-carbinol and oltipraz have an impact on the biochemical barrier against BP in intestinal cells. Benzo(a)pyrene cytochrome P450 family 1 subfamily B member 1 Homo sapiens
2 In summary, our study shows that the induction of both CYP1A1 and CYP1B1 resulted in an accelerated metabolism and an enhanced clearance of the potent procarcinogen BP, indicating that flavone, indole-3-carbinol and oltipraz have an impact on the biochemical barrier against BP in intestinal cells. Benzo(a)pyrene cytochrome P450 family 1 subfamily B member 1 Homo sapiens