Title : Inhibition of extracellular signal regulated kinase (ERK) leads to apoptosis inducing factor (AIF) mediated apoptosis in epithelial breast cancer cells: the lack of effect of ERK in p53 mediated copper induced apoptosis.

Pub. Date : 2005 Aug 15

PMID : 15880691






2 Functional Relationships(s)
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1 Furthermore, inhibition of ERK through addition of PD98059 stimulated p53 activation in MCF7 cells and also led to upregulation of p53 downstream targets, p21 and Bax, which is a proapototic member of Bcl-2 family triggering mitochondrial pore opening. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one tumor protein p53 Homo sapiens
2 Furthermore, inhibition of ERK through addition of PD98059 stimulated p53 activation in MCF7 cells and also led to upregulation of p53 downstream targets, p21 and Bax, which is a proapototic member of Bcl-2 family triggering mitochondrial pore opening. 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one tumor protein p53 Homo sapiens