Pub. Date : 2005 Apr 30
PMID : 15879708
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | When extracellular pH ([pH]o) was reduced to pH 6.4, COX-2 mRNA increased, with a peak at 2 h. This was blocked by pretreatment with actinomycin D and incubation with spermine NONOate (SPER/NO, a nitric oxide donor). | Nitric Oxide | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 2 | These data demonstrate that COX-2 expression is stimulated by the lowering of extracellular pH that could result from bacterial infection, and that this is countered by over-production of nitric oxide, which could also result from bacterial infection. | Nitric Oxide | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |