Pub. Date : 2005 Jun 15
PMID : 15876424
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Role of P-glycoprotein in transplacental transfer of methadone. | Methadone | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | We hypothesized that the expression and activity of the placental efflux transporter P-glycoprotein (P-gp) would affect the transfer of methadone to the fetal circulation. | Methadone | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | We hypothesized that the expression and activity of the placental efflux transporter P-glycoprotein (P-gp) would affect the transfer of methadone to the fetal circulation. | Methadone | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | Data obtained utilizing dual perfusion of placental lobule and monolayers of Be-Wo cell line indicated that methadone is extruded by P-gp. | Methadone | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 5 | Transfer of methadone to the fetal circuit was increased by 30% in the presence of the P-gp inhibitor GF120918 while the transfer of paclitaxel, a typical substrate of the glycoprotein, was increased by 50%. | Methadone | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 6 | In the Be-Wo cell line, methadone and paclitaxel uptake was also increased in the presence of the P-gp inhibitor cyclosporin A. | Methadone | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 7 | Taken together, these data strongly suggest that the concentration of methadone in the fetal circulation is affected by the expression and activity of P-gp. | Methadone | ATP binding cassette subfamily B member 1 | Homo sapiens |