Pub. Date : 2005 Apr
PMID : 15876410
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We have tested the effects of two Eli-Lilly compounds, LY 117, 018 and raloxifene, on E2-regulated and IGF-I-induced proliferation or AP-1 activity in human breast cancer cells. | Raloxifene Hydrochloride | insulin like growth factor 1 | Homo sapiens |
| 2 | Moreover, raloxifene was the most efficient molecule to prevent IGF-I-induced AP-1 activity, with a significant effect observed with a concentration as low as 5 x 10(-11)M in the presence of IGF-I alone. | Raloxifene Hydrochloride | insulin like growth factor 1 | Homo sapiens |
| 3 | Moreover, raloxifene was the most efficient molecule to prevent IGF-I-induced AP-1 activity, with a significant effect observed with a concentration as low as 5 x 10(-11)M in the presence of IGF-I alone. | Raloxifene Hydrochloride | insulin like growth factor 1 | Homo sapiens |
| 4 | Our data altogether demonstrate that raloxifene has a potent inhibitory effect on IGF-I action, with a drastic effect on AP-1 triggered responses as well as on Akt phosphorylation, suggesting that it might be a useful therapeutic agent in tumors in which these signalling pathways become constitutively active. | Raloxifene Hydrochloride | insulin like growth factor 1 | Homo sapiens |