Title : Mutant SOD1 alters the motor neuronal transcriptome: implications for familial ALS.

Pub. Date : 2005 Jul

PMID : 15872021






1 Functional Relationships(s)
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1 We provide evidence that dysregulation of Nrf2 and the ARE, coupled with reduced pentose phosphate pathway activity and decreased generation of NADPH, represent significant and hitherto unrecognized components of the toxic gain of function of mutant SOD1. NADP NFE2 like bZIP transcription factor 2 Homo sapiens