Title : IFN-gamma-enhanced allergen penetration across respiratory epithelium augments allergic inflammation.

Pub. Date : 2005 May

PMID : 15867854






2 Functional Relationships(s)
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1 A screening of various factors (histamine, IFN-gamma, IL-1beta, IL-2, IL-3, IL-4, IL-5, IL-8, IL-12, and TNF-alpha) identified IFN-gamma as a potent factor capable of reducing epithelial barrier properties and enhancing transepithelial allergen penetration. Histamine interferon gamma Homo sapiens
2 Increased submucosal allergen concentrations caused by IFN-gamma-mediated reduction of epithelial barrier function provoked a more than 7-fold augmentation of histamine release from sensitized basophils. Histamine interferon gamma Homo sapiens