Title : Mitochondrial respiratory chain and NAD(P)H oxidase are targets for the antiproliferative effect of carbon monoxide in human airway smooth muscle.

Pub. Date : 2005 Jul 8

PMID : 15863496






1 Functional Relationships(s)
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1 Carbon monoxide (CO), one of the end products of heme oxygenase activity, inhibits smooth muscle proliferation by decreasing ERK1/2 phosphorylation and cyclin D1 expression, a signaling pathway that is known to be modulated by reactive oxygen species (ROS) in airway smooth muscle cells (ASMCs). Reactive Oxygen Species mitogen-activated protein kinase 3 Homo sapiens