Pub. Date : 2005 Aug 15
PMID : 15860671
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Ectopic and IFN-induced expression of Fas overcomes resistance to Fas-mediated apoptosis in multiple myeloma cells. | ammonium ferrous sulfate | interferon alpha 1 | Homo sapiens |
| 2 | In addition, IFN treatment attenuated the interleukin 6 (IL-6)-dependent activation of signal transducer and activator of transcription 3 (Stat3), interfering with a known survival pathway in MM that has previously been linked with resistance to Fas-mediated apoptosis. | ammonium ferrous sulfate | interferon alpha 1 | Homo sapiens |
| 3 | Taken together, our results show that IFN-induced up-regulation of Fas sensitizes MM cells to Fas-mediated apoptosis and suggest that attenuation of Stat3 activation may be a potentially important event in this process. | ammonium ferrous sulfate | interferon alpha 1 | Homo sapiens |