Title : Functional analysis of six human aryl hydrocarbon receptor variants in a Japanese population.

Pub. Date : 2005 Aug

PMID : 15860653






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The luciferase reporter assay using the CYP1A1 promoter reporter in HeLa cells treated with beta-naphthoflavone or 3-methylcholanthrene, which are known as typical agonists for AhR, showed that reporter activities of the K401R and N487D variants were reduced to 40 to 58% of those of wild-type (WT) but not of the other variants. Methylcholanthrene cytochrome P450 family 1 subfamily A member 1 Homo sapiens