Title : Differential inhibition of cellular glutathione reductase activity by isocyanates generated from the antitumor prodrugs Cloretazine and BCNU.

Pub. Date : 2005 May 15

PMID : 15857610






2 Functional Relationships(s)
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1 Differential inhibition of cellular glutathione reductase activity by isocyanates generated from the antitumor prodrugs Cloretazine and BCNU. laromustine glutathione-disulfide reductase Homo sapiens
2 The superior antineoplastic potential of Cloretazine compared to BCNU in animal models could be attributed in part to the contribution of the methyl isocyanate, which is synergistic with the co-generated cytotoxic alkylating species, while at the same time unable to significantly inhibit cellular GR. laromustine glutathione-disulfide reductase Homo sapiens