Pub. Date : 2005 May 15
PMID : 15857610
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Differential inhibition of cellular glutathione reductase activity by isocyanates generated from the antitumor prodrugs Cloretazine and BCNU. | laromustine | glutathione-disulfide reductase | Homo sapiens |
| 2 | The superior antineoplastic potential of Cloretazine compared to BCNU in animal models could be attributed in part to the contribution of the methyl isocyanate, which is synergistic with the co-generated cytotoxic alkylating species, while at the same time unable to significantly inhibit cellular GR. | laromustine | glutathione-disulfide reductase | Homo sapiens |