Pub. Date : 2005 May
PMID : 15855635
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dibutyryl cAMP increased phosphorylation of Akt and CREB, both of which were reversed by H89, wortmannin and the Akt inhibitor SH-6. | Cyclic AMP | cAMP responsive element binding protein 1 | Mus musculus |
| 2 | In dominant-negative CREB-transfected cells, dibutyryl cAMP no longer prevented cell injury or inhibited changes in mRNA expression of Bcl-2 and Bax. | Cyclic AMP | cAMP responsive element binding protein 1 | Mus musculus |
| 3 | These findings suggest that elevation of endogenous cAMP effectively prevents radiocontrast nephropathy through activation of A kinase/PI 3-kinase/Akt followed by CREB phosphorylation and enhanced expression of Bcl-2. | Cyclic AMP | cAMP responsive element binding protein 1 | Mus musculus |