Pub. Date : 1992 May
PMID : 1585469
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The importance of thiopurine methyltransferase activity for the use of azathioprine in transplant recipients. | Azathioprine | thiopurine S-methyltransferase | Homo sapiens |
| 2 | TPMT activity in these 24 patients was also significantly lower than the general group of azathioprine-treated recipients. | Azathioprine | thiopurine S-methyltransferase | Homo sapiens |
| 3 | This inverse association between TPMT activity and allograft function was again found among 30 patients receiving triple therapy (azathioprine, CsA, prednisolone). | Azathioprine | thiopurine S-methyltransferase | Homo sapiens |
| 4 | We conclude that total intolerance to azathioprine is rare and usually appears in patients with very low TPMT activities. | Azathioprine | thiopurine S-methyltransferase | Homo sapiens |
| 5 | Our results also suggest that the wide range of TPMT activity may be an important factor in determining long-term graft survival in azathioprine-treated patients; those with high activity might benefit from doses near the upper limit generally recommended. | Azathioprine | thiopurine S-methyltransferase | Homo sapiens |