Title : The importance of thiopurine methyltransferase activity for the use of azathioprine in transplant recipients.

Pub. Date : 1992 May

PMID : 1585469






1 Functional Relationships(s)
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1 The immunosuppressive efficacy of azathioprine is related to its rapid metabolism in vivo to 6-mercaptopurine (6MP), with subsequent conversion to thioguanine nucleotides by an anabolic route involving hypoxanthine-guanine phosphoribosyltransferase. Azathioprine hypoxanthine phosphoribosyltransferase 1 Homo sapiens