Pub. Date : 2005 May 3
PMID : 15854583
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Isatin itself antagonised not only natriuretic peptide receptor type A (NPR-A) (ANP-stimulation of guanylyl cyclase) but also NPR-C (ANP and CNP mediated inhibition of adenylyl cyclase) signalling. | Isatin | natriuretic peptide receptor 1 | Rattus norvegicus |
| 2 | Isatin itself antagonised not only natriuretic peptide receptor type A (NPR-A) (ANP-stimulation of guanylyl cyclase) but also NPR-C (ANP and CNP mediated inhibition of adenylyl cyclase) signalling. | Isatin | natriuretic peptide receptor 1 | Rattus norvegicus |
| 3 | These results suggest that some [3H]isatin binding in the brain may be to NPR-A and NPR-C. | Isatin | natriuretic peptide receptor 1 | Rattus norvegicus |
| 4 | Competitive interactions between isatin and natriuretic peptides and their receptors give a possible explanation of the known anxiogenic effect of low doses of isatin, interacting at NPR-A, and the sedative effects of higher doses, antagonising respectively the anxiolytic effect of ANP and the anxiogenic effect of CNP. | Isatin | natriuretic peptide receptor 1 | Rattus norvegicus |
| 5 | Competitive interactions between isatin and natriuretic peptides and their receptors give a possible explanation of the known anxiogenic effect of low doses of isatin, interacting at NPR-A, and the sedative effects of higher doses, antagonising respectively the anxiolytic effect of ANP and the anxiogenic effect of CNP. | Isatin | natriuretic peptide receptor 1 | Rattus norvegicus |