Title : Metabolism of trans,trans-muconaldehyde by aldehyde and alcohol dehydrogenases: identification of a novel metabolite.

Pub. Date : 1992 May

PMID : 1585367






2 Functional Relationships(s)
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1 In the presence of NAD(+)-fortified ALDH, the mono-oxidation product (acid/aldehyde) was the primary metabolite formed with trace amounts of the dioxidation product (trans,trans-muconic acid). Aldehydes aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus
2 ALDH-mediated oxidation of a synthetic standard of the hydroxy/aldehyde derivative of MA resulted in formation of this new metabolite, which was also a major product formed by rat hepatocytes incubated with MA. Aldehydes aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus