Title : GABAA receptor gamma 2 subunit knockdown mice have enhanced anxiety-like behavior but unaltered hypnotic response to benzodiazepines.

Pub. Date : 2005 Apr 25

PMID : 15850489






1 Functional Relationships(s)
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1 CONCLUSION: We conclude that: 1) insertion of a neomycin resistance gene into intron 8 of the gamma2 gene variably reduced the amount of gamma2, and that 2) attenuated expression of gamma2 increased anxiety-like behaviors but did not lead to differences in the hypnotic response to benzodiazepine site ligands. Benzodiazepines gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2 Mus musculus