Pub. Date : 2005 Jul
PMID : 15843491
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Significant (p < 0.05) inhibition by selective P450 isoform inhibitor sulfaphenazole (2.1 microM; CYP2C9) indicated a role for CYP2C9 in the formation of the hydroxylamine. | Hydroxylamine | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 2 | Significant (p < 0.05) inhibition by selective P450 isoform inhibitor sulfaphenazole (2.1 microM; CYP2C9) indicated a role for CYP2C9 in the formation of the hydroxylamine. | Hydroxylamine | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |
| 3 | Fluconazole (CYP2C9/19 and CYP3A4 inhibitor at clinical concentrations) inhibited hydroxylamine formation, with one-enzyme model K(i) estimates ranging from 9 to 40 microM. | Hydroxylamine | cytochrome P450 family 2 subfamily C member 9 | Homo sapiens |