Pub. Date : 2005 May
PMID : 15842525
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of dipeptidyl peptidase IV activity by oral metformin in Type 2 diabetes. | Metformin | dipeptidyl peptidase 4 | Homo sapiens |
| 2 | We investigated the acute effects of metformin on DPP IV activity in Type 2 diabetes to elucidate inhibition of DPP IV as a possible mechanism of action. | Metformin | dipeptidyl peptidase 4 | Homo sapiens |
| 3 | RESULTS: Following metformin, DPP IV activity was suppressed compared with placebo (AUC0-6 h 3230+/-373 vs. 5764+/-504 nmol ml/l, respectively, P=0.001). | Metformin | dipeptidyl peptidase 4 | Homo sapiens |
| 4 | Metformin also concentration-dependently inhibited endogenous DPP IV activity in vitro in plasma from Type 2 diabetic subjects. | Metformin | dipeptidyl peptidase 4 | Homo sapiens |
| 5 | CONCLUSION: Oral metformin effectively inhibits DPP IV activity in Type 2 diabetic patients, suggesting that the drug may have potential for future combination therapy with incretin hormones. | Metformin | dipeptidyl peptidase 4 | Homo sapiens |