Title : A-425619 [1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea], a novel and selective transient receptor potential type V1 receptor antagonist, blocks channel activation by vanilloids, heat, and acid.

Pub. Date : 2005 Jul

PMID : 15837819






2 Functional Relationships(s)
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1 The vanilloid receptor transient receptor potential type V1 (TRPV1) integrates responses to multiple stimuli, such as capsaicin, acid, heat, and endovanilloids and plays an important role in the transmission of inflammatory pain. Capsaicin transient receptor potential cation channel subfamily V member 1 Homo sapiens
2 A-425619 was found to potently block capsaicin-evoked increases in intracellular calcium concentrations in HEK293 cells expressing recombinant human TRPV1 receptors (IC50 = 5 nM). Capsaicin transient receptor potential cation channel subfamily V member 1 Homo sapiens