Title : Rationale and design of the DIRECT study: a comparative assessment of the hyperglycemic effects of tacrolimus and cyclosporine following renal transplantation.

Pub. Date : 2005 Feb

PMID : 15837449






1 Functional Relationships(s)
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1 Evidence from large-scale analyses of registry databases has shown that the calcineurin inhibitor, tacrolimus, is associated with approximately a 50% increase in the risk of NODM compared to the microemulsion formulation of cyclosporine (CsA); but to date, little robust evidence is available from clinical trials. Cyclosporine calcineurin binding protein 1 Homo sapiens