Title : Interleukin-1 antagonizes morphine analgesia and underlies morphine tolerance.

Pub. Date : 2005 May

PMID : 15836969






1 Functional Relationships(s)
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1 We report that administration of a neutral dose of IL-1beta abolished morphine analgesia in mice, whereas acute or chronic blockade of IL-1 signaling by various IL-1 blockers (IL-1 receptor antagonist (IL-1ra), alpha-melanocyte-stimulating hormone, or IL-1 tri-peptide antagonist) significantly prolonged and potentiated morphine analgesia. Morphine interleukin 1 beta Mus musculus