Pub. Date : 2005 May
PMID : 15836624
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The phosphorylation of cAMP-responsive element binding protein (CREB) and induction of c-Fos in response to cAMP were strongly suppressed in Neuro2a cells expressing expanded polyglutamine. | Cyclic AMP | cAMP responsive element binding protein 1 | Mus musculus |
| 2 | The suppression of CREB-dependent transcriptional activation was reversibly rescued by increasing the concentration of cAMP. | Cyclic AMP | cAMP responsive element binding protein 1 | Mus musculus |
| 3 | Expanded polyglutamine-induced cytotoxicity was also substantially suppressed by augmenting CREB-dependent transcriptional activation with a high concentration of cAMP. | Cyclic AMP | cAMP responsive element binding protein 1 | Mus musculus |
| 4 | The co-expression of dominant-negative CREB vectors considerably abrogated the suppressive effect of cAMP and FR901228 on the expanded polyglutamine-induced nuclear fragmentation, suggesting that these compounds suppress polyglutamine-induced cytotoxicity, largely, via the enhancement of CREB-dependent transcriptional activation. | Cyclic AMP | cAMP responsive element binding protein 1 | Mus musculus |
| 5 | The co-expression of dominant-negative CREB vectors considerably abrogated the suppressive effect of cAMP and FR901228 on the expanded polyglutamine-induced nuclear fragmentation, suggesting that these compounds suppress polyglutamine-induced cytotoxicity, largely, via the enhancement of CREB-dependent transcriptional activation. | Cyclic AMP | cAMP responsive element binding protein 1 | Mus musculus |