Title : Induction of phase I, II and III drug metabolism/transport by xenobiotics.

Pub. Date : 2005 Mar

PMID : 15832810






1 Functional Relationships(s)
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1 Similarly, the steroid family of orphan nuclear receptors, the constitutive androstane receptor (CAR) and pregnane X receptor (PXR), both heterodimerize with the retinoid X receptor (RXR), are shown to transcriptionally activate the promoters of CYP2B and CYP3A gene expression by xenobiotics such as phenobarbital-like compounds (CAR) and dexamethasone and rifampin-type of agents (PXR). Phenobarbital cytochrome P450 family 3 subfamily A member 4 Homo sapiens