Title : Differential effects of the immunosuppressant FK-506 on human alpha2(I) collagen gene expression and transforming growth factor beta signaling in normal and scleroderma fibroblasts.

Pub. Date : 2005 Apr

PMID : 15818662






1 Functional Relationships(s)
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1 RESULTS: FK-506 did not affect the basal expression of type I procollagen protein or alpha2(I) collagen mRNA, but it significantly reduced the TGFbeta1-induced expression of type I procollagen protein and alpha2(I) collagen mRNA in normal fibroblasts. Tacrolimus transforming growth factor beta 1 Homo sapiens