Title : Lack of oestrogen protection in amyloid-mediated endothelial damage due to protein nitrotyrosination.

Pub. Date : 2005 Jul

PMID : 15817516






2 Functional Relationships(s)
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1 Here we show that E2-mediated activation of endothelial nitric oxide synthase (eNOS) increases the production of nitric oxide (NO), which, under Abeta(E22Q)-induced oxidative damage, results in the formation of peroxynitrite and increased nitration of tyrosine residues. Tyrosine nitric oxide synthase 3 Homo sapiens
2 Here we show that E2-mediated activation of endothelial nitric oxide synthase (eNOS) increases the production of nitric oxide (NO), which, under Abeta(E22Q)-induced oxidative damage, results in the formation of peroxynitrite and increased nitration of tyrosine residues. Tyrosine nitric oxide synthase 3 Homo sapiens