Pub. Date : 2005 Jun 24
PMID : 15817479
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Bcl-2 rescues ceramide- and etoposide-induced mitochondrial apoptosis through blockage of caspase-2 activation. | Etoposide | BCL2 apoptosis regulator | Homo sapiens |
| 2 | Overexpression of Bcl-2 prevented ceramide- and etoposide-induced caspase-2 activation and mitochondrial apoptosis. | Etoposide | BCL2 apoptosis regulator | Homo sapiens |
| 3 | Further studies showed that Bcl-2 was dephosphorylated at serine 70 after ceramide and etoposide treatment. | Etoposide | BCL2 apoptosis regulator | Homo sapiens |
| 4 | Taken together, ceramide and etoposide induced mitochondria-mediated apoptosis by initiating caspase-2 activation, which was, at least in part, regulated by Bcl-2. | Etoposide | BCL2 apoptosis regulator | Homo sapiens |