Title : 32P-postlabeling analysis of DNA adduction in mouse skin following topical administration of (+)-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene.

Pub. Date : 1992 Jan-Feb

PMID : 1581533






1 Functional Relationships(s)
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1 The stereochemistry of epoxidation of the enantiomers of BP-7,8-diol indicates that cytochrome P-450 catalyzes the terminal activation step of benzo[a]pyrene activation to an ultimate carcinogen in mouse skin, a target organ for its carcinogenic activity. Benzo(a)pyrene cytochrome P450, family 21, subfamily a, polypeptide 1 Mus musculus