Pub. Date : 2005 Apr
PMID : 15801936
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | All patients were genotyped for allelic variants in genes encoding drug metabolizing enzymes (CYP3A4, CYP3A5, UGT1A1) and drug transporters (ABCB1, ABCC2 and ABCG2) that are involved in irinotecan disposition. | Irinotecan | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | The C(max) of irinotecan was significantly lower in patients carrying the CC genotype at exon 26 of the ABCB1 gene compared with those harbouring at least one variant allele (P = 0.047). | Irinotecan | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | CONCLUSIONS: The present exploratory study shows that genetic polymorphisms in drug transporter genes, particularly in ABCB1 and ABCG2 genes, may be important in influencing the pharmacokinetics of irinotecan and its metabolites. | Irinotecan | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 4 | The predictive value of the identified allelic variants in the ABCG2 and ABCB1 genes on irinotecan disposition should be further investigated in a larger patient population as well as in other ethnic populations. | Irinotecan | ATP binding cassette subfamily B member 1 | Homo sapiens |