Title : The importance of the amide bond nearest the thiol group in enzymatic reactions of coenzyme A.

Pub. Date : 2005 Apr

PMID : 15788165






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 An analogue of acetyl-CoA in which this amide bond is replaced with an ester linkage was a good substrate for the enzymes carnitine acetyltransferase, chloramphenicol acetyltransferase, and citrate synthase, with K(m) values 2- to 8-fold higher than those of acetyl-CoA and V(max) values from 14 to >80% those of the natural substrate. Acetyl Coenzyme A citrate synthase Homo sapiens
2 An analogue of acetyl-CoA in which this amide bond is replaced with an ester linkage was a good substrate for the enzymes carnitine acetyltransferase, chloramphenicol acetyltransferase, and citrate synthase, with K(m) values 2- to 8-fold higher than those of acetyl-CoA and V(max) values from 14 to >80% those of the natural substrate. Acetyl Coenzyme A citrate synthase Homo sapiens